Error 21408 indicates that you have not yet enabled permission to send messages to the region indicated by the "To" number you are trying to send a message to. This setting ensures that you are not getting invoiced with unexpected charges and that you send SMS to regions only where you decide to operate.
You have to enable permission to send SMS to the region in question by visiting the Geo-Permissions settings of your account.
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Send up to 10,000 notifications every month, for free.
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